The Oakleys head to Kodiak Island with a special guest in tow, their pet pug. Daisy's having a tough time with a growing mast cell tumor, but a new drug offers an unexpected opportunity to extend her life. While juggling the pressures of caring for Daisy, the team investigates a lump on a beloved horse, and joins an indigenous tribe in an effort to move 66 wild bison to a remote island. But for any hope of success, they must employ horses and helicopters to outsmart the herd.